Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

Eccles, J.A., Beacher, F.D.C., Gray, M.A., Jones, C.L., Minati, L., Harrison, N.A. and Critchley, H.D. 2012. Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. British Journal of Psychiatry 200 (6) , pp. 508-509. 10.1192/bjp.bp.111.092460

Full text not available from this repository.

Abstract

Joint hypermobility is overrepresented among people with anxiety and can be associated with abnormal autonomic reactivity. We tested for associations between regional cerebral grey matter and hypermobility in 72 healthy volunteers using voxel-based morphometry of structural brain scans. Strikingly, bilateral amygdala volume distinguished those with from those without hypermobility. The hypermobility group scored higher for interoceptive sensitivity yet were not significantly more anxious. Our findings specifically link hypermobility to the structural integrity of a brain centre implicated in normal and abnormal emotions and physiological responses. Our observations endorse hypermobility as a multisystem phenotype and suggest potential mechanisms mediating clinical vulnerability to neuropsychiatric symptoms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Cambridge University Press (CUP)
ISSN: 0007-1250
Last Modified: 14 May 2019 10:50
URI: http://orca.cf.ac.uk/id/eprint/121431

Citation Data

Cited 31 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item