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Late recurrences of Sydenham's chorea are not associated with anti-basal ganglia antibodies

Harrison, N.A., Church, A., Nisbet, A., Rudge, P. and Giovannoni, G. 2004. Late recurrences of Sydenham's chorea are not associated with anti-basal ganglia antibodies. Journal of Neurology, Neurosurgery and Psychiatry 75 (10) , pp. 1478-1479. 10.1136/jnnp.2003.030775

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Abstract

Anti-basal ganglia antibodies (ABGA) have been associated with 100% of acute cases and 69% of persistent cases of Sydenham’s chorea. We describe two cases of late recurrences of Sydenham’s chorea with absence of ABGA. Both patients had several childhood episodes of Sydenham’s chorea. MRI imaging of the basal ganglia and exhaustive investigations for other causes of chorea were normal or negative. The absence of ABGA may be evidence against an autoimmune pathology in late and some persistent recurrences. We suggest the likely pathophysiology to be dopamine hypersensitivity of chronically damaged basal ganglia neurones possibly following induction of an autoimmune antibody response in childhood.

Item Type: Article
Status: Published
Schools: Medicine
ISSN: 0022-3050
Last Modified: 25 Apr 2019 15:15
URI: http://orca.cf.ac.uk/id/eprint/121451

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