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Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task

Voon, V., Irvine, M.A., Derbyshire, K., Worbe, Y., Lange, I., Abbott, S., Morein-Zamir, S., Dudley, R., Caprioli, D., Harrison, N.A., Wood, J., Dalley, J.W., Bullmore, E.T., Grant, J.E. and Robbins, T.W. 2014. Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task. Biological Psychiatry 75 (2) , pp. 148-155. 10.1016/j.biopsych.2013.05.013

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Abstract

BackgroundPremature responding is a form of motor impulsivity that preclinical evidence has shown to predict compulsive drug seeking but has not yet been studied in humans. We developed a novel translation of the task, based on the rodent 5-choice serial reaction time task, testing premature responding in disorders of drug and natural food rewards.MethodsAbstinent alcohol- (n = 30) and methamphetamine-dependent (n = 23) subjects, recreational cannabis users (n = 30), and obese subjects with (n = 30) and without (n = 30) binge eating disorder (BED) were compared with matched healthy volunteers and tested on the premature responding task.ResultsCompared with healthy volunteers, alcohol- and methamphetamine-dependent subjects and cannabis users showed greater premature responding with no differences observed in obese subjects with or without BED. Current smokers exhibited greater premature responding versus ex-smokers and nonsmokers. Alcohol-dependent subjects also had lower motivation for explicit monetary incentives. A Motivation Index correlated negatively with alcohol use and binge eating severity.ConclusionsPremature responding on a novel translation of a serial reaction time task was more evident in substance use disorders but not in obese subjects with or without BED. Lower motivation for monetary incentives linked alcohol use and binge eating severity. Our findings add to understanding the relationship between drug and natural food rewards.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0006-3223
Last Modified: 15 May 2019 10:46
URI: http://orca.cf.ac.uk/id/eprint/121501

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