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A novel framework to measure executive function in Down syndrome, with applications for early clinical diagnosis of dementia

Smith, Elizabeth, Hedge, Craig and Jarrold, Christopher 2019. A novel framework to measure executive function in Down syndrome, with applications for early clinical diagnosis of dementia. American Journal on Intellectual and Developmental Disabilities 124 (4) , pp. 354-373. 10.1352/1944-7558-124.4.354

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Abstract

Executive function (EF) decline is a consistent early sign of Alzheimer's disease (AD) among adults with Down syndrome (DS), which means that baseline measures of EF for individuals with DS are vital to allow detection of meaningful decline. We developed a framework to extract measures of three core components of EF (memory updating, inhibitory, and temporal components) within one task. Increases in memory load, inhibitory load, and temporal demands led to significant increases in reaction times and significant decreases in accuracy among 18 adults with DS and 18 typically developing matched individuals; thus, the expected effects of all three manipulations were detected. Good test-retest reliability indicated that this framework has the potential to provide a simple, baseline EF measure for individuals with DS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Publisher: American Association on Intellectual and Developmental Disabilities (AAIDD)
ISSN: 1944-7558
Date of First Compliant Deposit: 15 April 2019
Date of Acceptance: 11 March 2019
Last Modified: 31 Oct 2019 00:45
URI: http://orca.cf.ac.uk/id/eprint/121769

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