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Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes.

Mizuta, S, Stenhagen, I S, O'Duill, M, Wolstenhulme, J, Kirjavainen, A K, Forsback, S J, Tredwell, M, Sandford, G, Moore, P R, Huiban, M, Luthra, S K, Passchier, J, Solin, O and Gouverneur, V 2013. Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes. Organic Letters 15 (11) , pp. 2648-2651. 10.1021/ol4009377

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Abstract

Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [(18)F]labeling is demonstrated using [(18)F]Selectfluor bis(triflate), a reagent affording [(18)F]tri- and [(18)F]difluoromethylarenes not within reach with [(18)F]F2.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 11 Jun 2019 15:15
URI: http://orca.cf.ac.uk/id/eprint/122215

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