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The Superoanterior Fasciculus (SAF): a novel white matter pathway in the human brain?

David, Szabolcs, Heemskerk, Anneriet M., Corrivetti, Francesco, Thiebaut de Schotten, Michel, Sarubbo, Silvio, Corsini, Francesco, De Benedictis, Alessandro, Petit, Laurent, Viergever, Max A., Jones, Derek K., Mandonnet, Emmanuel, Axer, Hubertus, Evans, John, Paus, Tomás and Leemans, Alexander 2019. The Superoanterior Fasciculus (SAF): a novel white matter pathway in the human brain? Frontiers in Neuroanatomy 13 , -. 10.3389/fnana.2019.00024

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Abstract

Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain’s circuitry with FT is not without controversy, recent progress in acquisition, processing, modeling, analysis, and visualization of dMRI data pushes forward the reliability in reconstructingWMpathways. Despite being aware of the well-known pitfalls in analyzing dMRI data and several other limitations of FT discussed in recent literature, we present the superoanterior fasciculus (SAF), a novel bilateral fiber tract in the frontal region of the human brain that—to the best of our knowledge—has not been documented. The SAF has a similar shape to the anterior part of the cingulum bundle, but it is locatedmore frontally. To minimize the possibility that these FT findings are based on acquisition or processing artifacts, different dMRI data sets and processing pipelines have been used to describe the SAF.Furthermore,weevaluated the configurationof theSAFwithcomplementarymethods, such as polarized light imaging (PLI) and human brain dissections. The FT results of the SAF demonstrate a long pathway, consistent across individuals, while the human dissections indicate fiber pathwaysconnecting the postero-dorsal with the antero-dorsal cortices of the frontal lobe.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Publisher: Frontiers
ISSN: 1662-5129
Date of First Compliant Deposit: 9 May 2019
Date of Acceptance: 7 February 2019
Last Modified: 09 May 2019 09:45
URI: http://orca.cf.ac.uk/id/eprint/122261

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