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Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols

Dambatta, Mubarak, Polidano, Kurt, Northey, Alexander D., Williams, Jonathan M. J. and Morrill, Louis C. 2019. Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols. ChemSusChem 12 (11) , pp. 2345-2349. 10.1002/cssc.201900799

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Abstract

A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employs a (cyclopentadienone)iron carbonyl complex (2 mol %) and exhibits a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles undergo selective monoC(3)-alkylation in good to excellent isolated yields (28 examples, 50- 92% yield, 79% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 1864-5631
Funders: EPSRC
Date of First Compliant Deposit: 14 May 2019
Date of Acceptance: 8 April 2019
Last Modified: 02 May 2020 00:43
URI: http://orca.cf.ac.uk/id/eprint/122469

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