Dambatta, Mubarak, Polidano, Kurt, Northey, Alexander D., Williams, Jonathan M. J. and Morrill, Louis C.
2019.
Iron‐catalyzed borrowing hydrogen C‐Alkylation of oxindoles with alcohols.
ChemSusChem
12
(11)
, pp. 2345-2349.
10.1002/cssc.201900799
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Official URL: http://dx.doi.org/10.1002/cssc.201900799
Abstract
A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employs a (cyclopentadienone)iron carbonyl complex (2 mol %) and exhibits a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles undergo selective monoC(3)-alkylation in good to excellent isolated yields (28 examples, 50- 92% yield, 79% average yield).
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | Wiley |
ISSN: | 1864-5631 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 14 May 2019 |
Date of Acceptance: | 8 April 2019 |
Last Modified: | 20 Jan 2021 06:36 |
URI: | http://orca.cf.ac.uk/id/eprint/122469 |
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