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The photoreactivity of ocular lipofuscin

Boulton, Michael Edwin, Rozanowska, Malgorzata Barbara, Rozanowski, Bartosz and Wess, Timothy James 2004. The photoreactivity of ocular lipofuscin. Photochemical and Photobiological Sciences 3 (8) , pp. 759-764. 10.1039/B400108G

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Abstract

Lipofuscin or “age pigment” is a lipid–protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: Royal Society of Chemistry
ISSN: 1474-905X
Last Modified: 04 Feb 2018 01:10
URI: http://orca.cf.ac.uk/id/eprint/12289

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