Process-based framework for precise neuromodulation

Lubianiker, Nitzan, Goldway, Noam, Fruchtman-Steinbok, Tom, Paret, Christian, Keynan, Jacob N., Singer, Neomi, Cohen, Avihay, Kadosh, Kathrin Cohen, Linden, David E. J. and Hendler, Talma 2019. Process-based framework for precise neuromodulation. Nature Human Behaviour 3 (5) , pp. 436-445. 10.1038/s41562-019-0573-y

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Abstract

Functional MRI neurofeedback (NF) allows humans to self-modulate neural patterns in specific brain areas. This technique is regarded as a promising tool to translate neuroscientific knowledge into brain-guided psychiatric interventions. However, its clinical implementation is restricted by unstandardized methodological practices, by clinical definitions that are poorly grounded in neurobiology, and by lack of a unifying framework that dictates experimental choices. Here we put forward a new framework, termed ‘process-based NF’, which endorses a process-oriented characterization of mental dysfunctions to form precise and effective psychiatric treatments. This framework relies on targeting specific dysfunctional mental processes by modifying their underlying neural mechanisms and on applying process-specific contextual feedback interfaces. Finally, process-based NF offers designs and a control condition that address the methodological shortcomings of current approaches, thus paving the way for a precise and personalized neuromodulation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Nature Publishing Group
ISSN:	2397-3374
Date of First Compliant Deposit:	28 May 2019
Date of Acceptance:	5 March 2019
Last Modified:	06 Nov 2023 20:24
URI:	https://orca.cardiff.ac.uk/id/eprint/122908

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