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H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

Schinkelshoek, M.S., Fronczek, R., Kooy-Winkelaar, E.M.C., Petersen, J., Reid, H.H., van der Heide, A., Drijfhout, J.W., Rossjohn, Jamie, Lammers, G.J. and Koning, F. 2019. H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. Journal of Neuroimmunology 332 , pp. 167-175. 10.1016/j.jneuroim.2019.04.009

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Abstract

Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0165-5728
Date of First Compliant Deposit: 28 May 2019
Date of Acceptance: 16 April 2019
Last Modified: 28 May 2019 14:54
URI: http://orca.cf.ac.uk/id/eprint/122911

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