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Executive "Brake Failure" following deactivation of human frontal lobe

Chambers, Christopher D., Bellgrove, Mark A., Stokes, Mark G., Henderson, Tracy R., Garavan, Hugh, Robertson, Ian H., Morris, Adam P. and Mattingley, Jason B. 2006. Executive "Brake Failure" following deactivation of human frontal lobe. Journal of Cognitive Neuroscience 18 (3) , pp. 444-455. 10.1162/jocn.2006.18.3.444

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In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 26/02/2014).
Publisher: MIT Press
ISSN: 0898-929x
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 02:48

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