Correlation of TERT and stem cell markers in the context of human breast cancer

Wazir, Umar, Orakzai, Mona M. A. W., Martin, Tracey Amanda, Jiang, Wen G. and Mokbel, Kefah 2019. Correlation of TERT and stem cell markers in the context of human breast cancer. Cancer Genomics and Proteomics 16 (2) , pp. 121-127. 10.21873/cgp.20117

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Abstract

Background: Telomerase reverse transcriptase (TERT) has a well-known role in carcinogenesis due to its functions in inducing cell immortality and preventing senescence. In this study, the relationships between TERT and a panel of known stem cell markers was examined in order to direct future enquiries into the role of ‘stem-ness’ in human breast cancer. Materials and Methods: Breast cancer tissues (n=124) and adjacent normal tissues (n=30) underwent reverse transcription and quantitative polymerase chain reaction. Transcript levels were analyzed for the correlation with that of TERT. Results: A significant direct correlation was found in cancerous tissue between TERT and BMI1 proto-oncogene polycomb ring finger 4 (BMI1; n=88, p<0.001), nestin (NES; n=88, p<0.001), POU domain, class 5, transcription factor 1 (POU5F1; n=88, p<0.001), aldehyde dehydrogenase 1 family member A2 (ALDH1A2; n=87, p=0.0298), cyclin-dependent kinase inhibitor 1A (CDKN1A; n=88, p<0.001), integrin subunit beta 1 (ITGNB1; n=88, p<0.001), integrin subunit alpha 6 (ITGA6; n=88, p<0.001), cluster of differentiation antigen 24 (CD24; n=88, p=0.0114), MET proto-oncogene (MET; n=78, p<0.001) and noggin (NOG; n=88, p<0.001). Conclusion: The evidence presented in this article of possible interactions between TERT and a discrete subset of known stem cell markers would significantly contribute to further enquiries regarding clonal dynamics in the context of human breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	International Institute of Anticancer Research (IIAR)
ISSN:	1109-6535
Date of First Compliant Deposit:	6 June 2019
Date of Acceptance:	26 February 2019
Last Modified:	20 Jan 2021 11:31
URI:	http://orca.cf.ac.uk/id/eprint/123245

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