Wazir, Umar, Orakzai, Mona M. A. W., Martin, Tracey Amanda, Jiang, Wen G. and Mokbel, Kefah
2019.
Correlation of TERT and stem cell markers in the context of human breast cancer.
Cancer Genomics and Proteomics
16
(2)
, pp. 121-127.
10.21873/cgp.20117
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Abstract
Background: Telomerase reverse transcriptase (TERT) has a well-known role in carcinogenesis due to its functions in inducing cell immortality and preventing senescence. In this study, the relationships between TERT and a panel of known stem cell markers was examined in order to direct future enquiries into the role of ‘stem-ness’ in human breast cancer. Materials and Methods: Breast cancer tissues (n=124) and adjacent normal tissues (n=30) underwent reverse transcription and quantitative polymerase chain reaction. Transcript levels were analyzed for the correlation with that of TERT. Results: A significant direct correlation was found in cancerous tissue between TERT and BMI1 proto-oncogene polycomb ring finger 4 (BMI1; n=88, p<0.001), nestin (NES; n=88, p<0.001), POU domain, class 5, transcription factor 1 (POU5F1; n=88, p<0.001), aldehyde dehydrogenase 1 family member A2 (ALDH1A2; n=87, p=0.0298), cyclin-dependent kinase inhibitor 1A (CDKN1A; n=88, p<0.001), integrin subunit beta 1 (ITGNB1; n=88, p<0.001), integrin subunit alpha 6 (ITGA6; n=88, p<0.001), cluster of differentiation antigen 24 (CD24; n=88, p=0.0114), MET proto-oncogene (MET; n=78, p<0.001) and noggin (NOG; n=88, p<0.001). Conclusion: The evidence presented in this article of possible interactions between TERT and a discrete subset of known stem cell markers would significantly contribute to further enquiries regarding clonal dynamics in the context of human breast cancer.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | International Institute of Anticancer Research (IIAR) |
ISSN: | 1109-6535 |
Date of First Compliant Deposit: | 6 June 2019 |
Date of Acceptance: | 26 February 2019 |
Last Modified: | 20 Jan 2021 11:31 |
URI: | http://orca.cf.ac.uk/id/eprint/123245 |
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