Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial)

Drew, Cheney J. G., Postans, Mark, Petralia, Cateno, McNamara, Rachel, Pallmann, Philip, Gillespie, David, Evans, Lisa, Muhlert, Nils, Winter, Mia, Hamandi, Khalid and Gray, William 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 10.1186/s40814-019-0474-x

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (857kB) | Preview

Abstract

People with temporal lobe epilepsy (TLE) report significant problems with learning and memory. There are no effective therapies for combatting these problems in people with TLE, resulting in an unmet therapeutic need. The lack of treatment is, in part, due to a poor understanding of the neurobiology underlying these memory deficits. We know that hippocampal neurogenesis, a process believed to be important in learning and memory formation, is permanently reduced in chronic TLE, and this may go some way to explain the learning and memory impairments seen in people with TLE. The common anti-depressant drug fluoxetine has been shown to stimulate neurogenesis both in the healthy brain and in neurological diseases where neurogenesis is impaired. In an animal model of TLE, administration of fluoxetine was found to restore neurogenesis and improve learning on a complex spatial navigational task. We now want to test this effect in humans by investigating whether administration of fluoxetine to people with TLE can improve learning and memory.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Psychology
Centre for Trials Research (CNTRR)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: BioMed Central
ISSN: 2055-5784
Date of First Compliant Deposit: 2 August 2019
Date of Acceptance: 26 June 2019
Last Modified: 03 Aug 2019 23:26
URI: http://orca.cf.ac.uk/id/eprint/124059

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics