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Product-like inhibitors of inositol monophosphatase

Bashir-Uddin Surfraz, M., Miller, David James., Gani, David and Allemann, Rudolf Konrad 2003. Product-like inhibitors of inositol monophosphatase. Tetrahedron Letters 44 (41) , pp. 7677-7679. 10.1016/S0040-4039(03)01878-1

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Abstract

A series of product-like inhibitors of inositol monophosphatase have been prepared and tested for activity in vitro as possible leads for treatment of bipolar disorders. Compounds possessing a 6-alkyloxy side chain were inhibitors but less efficacious than those possessing a 6-aminoalkyl side chain. These new structures show promise as inhibitors possessing the bioavailability and characteristics necessary for drug development. A series of product-like inhibitors of inositol monophosphatase have been prepared and tested for activity in vitro as possible leads for treatment of bipolar disorders. Compounds possessing a 6-alkyloxy side chain were inhibitors but less efficacious than those possessing a 6-aminoalkyl side chain. These new structures show promise as inhibitors possessing the bioavailability and characteristics necessary for drug development.

Item Type: Article
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
Publisher: Elsevier
ISSN: 0040-4039
Last Modified: 04 Jun 2017 02:49
URI: http://orca.cf.ac.uk/id/eprint/12499

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