Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Widespread white matter microstructural abnormalities in bipolar disorder: Evidence from mega- and meta-analyses across 3,033 individuals

Favre, Pauline, Pauling, Melissa, Stout, Jacques, Hozer, Franz, Sarrazin, Samuel, Abe, Christoph, Alda, Martin, Alloza, Clara, Alonso-Lana, Silvia, Andreassen, Ole A., Baune, Bernhard T., Benedetti, Francesca, Busatto, Geraldo F., Canales-Rodriguez, Erick J., Caseras, Xavier, Moukbel Chaim-Avancini, Tiffany, Ching, Christopher R. K., Dannlowski, Udo, Deppe, Michael, Eyler, Lisa T., Fatjo-Vilas, Mar, Foley, Sonya, Grotegerd, Dominik, Hajek, Tomas, Haukvik, Unn K., Howells, Fleur M., Jahanshad, Neda, Kugel, Harald, Lagerberg, Trine, Lawrie, Stephen M. and Linke, Julia O. 2019. Widespread white matter microstructural abnormalities in bipolar disorder: Evidence from mega- and meta-analyses across 3,033 individuals. Neuropsychopharmacology 10.1038/s41386-019-0485-6

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr < 0.001) and cingulum (right: R2 = 0.041, left: R2 = 0.040, Pcorr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Psychology
Publisher: Nature Publishing Group
ISSN: 0893-133X
Date of First Compliant Deposit: 19 August 2019
Date of Acceptance: 1 August 2019
Last Modified: 16 Oct 2019 15:31
URI: http://orca.cf.ac.uk/id/eprint/124995

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics