Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Premorbid adjustment and IQ in patients with first-episode psychosis: a multisite case-control study of their relationship with cannabis use

Ferraro, Laura, La Cascia, Caterina, Quattrone, Diego, Sideli, Lucia, Matranga, Domenica, Capuccio, Veronica, Tripoli, Giada, Gayer-Anderson, Charlotte, Morgan, Craig, Sami, Musa B, Sham, Pak, de Haan, Lieuwe, Velthorst, Eva, Jongsma, Hannah E, Kirkbride, James B, Rutten, Bart P F, Richards, Alexander L, Roldan, Laura, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Sanjuan, Julio, Santos, Jose Luis, Arrojo, Manuel, Tarricone, Ilaria, Tortelli, Andrea, Szöke, Andrei, Del-Ben, Cristina Marta, Selten, Jean-Paul, Lynskey, Michael, Jones, Peter B, Van Os, Jim, La Barbera, Daniele, Amoretti, Silvia, Baudin, Grégoire, Beards, Stephanie, Berardi, Domenico, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González Peñas, Javier, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Lasalvia, Antonio, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, M Díaz-Caneja, Covadonga, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Moreno, Carmen, Juan, Nacher, Olmeda, Ma Soledad, Parellada, Mara, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Rossi Menezes, Paulo, Ruggeri, Mirella, Sáiz, Pilar A, Sánchez-Gutierrez, Teresa, Sánchez, Emilio, Sartorio, Crocettarachele, Schurhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Murray, Robin M and Di Forti, Marta 2020. Premorbid adjustment and IQ in patients with first-episode psychosis: a multisite case-control study of their relationship with cannabis use. Schizophrenia Bulletin 46 (3) , pp. 517-529. 10.1093/schbul/sbz077

[thumbnail of Binder2.pdf]
Preview
PDF - Accepted Post-Print Version
Download (436kB) | Preview

Abstract

Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients with first-episode psychosis (FEP) and 1313 population controls across 6 countries, we examined the extent to which IQ and both early academic (Academic Factor [AF]) and social adjustment (Social Factor [SF]) are related to the lifetime frequency of cannabis use in both patients and controls. We expected a higher IQ and a better premorbid social adjustment in psychotic patients who had ever used cannabis compared to patients without any history of use. We did not expect such differences in controls. In both patients and controls, IQ was 3 points higher among occasional-users than in never-users (mean difference [Mdiff] = 2.9, 95% CI = [1.2, 4.7]). Both cases and control daily-users had lower AF compared to occasional (Mdiff = −0.3, 95% CI = [−0.5; −0.2]) and never-users (Mdiff = −0.4, 95% CI = [−0.6; −0.2]). Finally, patient occasional (Mdiff = 0.3, 95% CI = [0.1; 0.5]) and daily-users (Mdiff = 0.4, 95% CI = [0.2; 0.6]) had better SF than their never-using counterparts. This difference was not present in controls (Fgroup*frequency(2, 2205) = 4.995, P = .007). Our findings suggest that the better premorbid social functioning of FEP with a history of cannabis use may have contributed to their likelihood to begin using cannabis, exposing them to its reported risk-increasing effects for Psychotic Disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Oxford University Press
ISSN: 0586-7614
Date of First Compliant Deposit: 21 August 2019
Date of Acceptance: 24 June 2019
Last Modified: 06 Nov 2023 19:45
URI: https://orca.cardiff.ac.uk/id/eprint/125045

Citation Data

Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics