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Iron-catalyzed borrowing hydrogen β-C(sp3)-methylation of alcohols

Polidano, Kurt, Williams, Jonathan M. J. and Morrill, Louis C. 2019. Iron-catalyzed borrowing hydrogen β-C(sp3)-methylation of alcohols. ACS Catalysis 9 (9) , pp. 8575-8580. 10.1021/acscatal.9b02461

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Abstract

Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: American Chemical Society
ISSN: 2155-5435
Funders: EPSRC
Date of First Compliant Deposit: 22 August 2019
Date of Acceptance: 15 August 2019
Last Modified: 16 Sep 2020 17:00
URI: http://orca.cf.ac.uk/id/eprint/125064

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