Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Mammalian sphingoid bases: Biophysical, physiological and pathological properties

Carreira, A.C., Santos, T.C., Lone, M.A., Zupancic, E., Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, de Almeida, R.F.M., Hornemann, T. and Silva, L.C. 2019. Mammalian sphingoid bases: Biophysical, physiological and pathological properties. Progress in Lipid Research 75 , 100988. 10.1016/j.plipres.2019.100988

[thumbnail of Mammalian sphingoid bases- 2nd revision.pdf]
Preview
PDF - Accepted Post-Print Version
Download (947kB) | Preview

Abstract

Sphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules, and have been associated with numerous biological and physiological processes. In addition, they can modulate the biophysical properties of biological membranes. Several human diseases are related to pathological changes in the structure and metabolism of sphingoid bases. Yet, the mechanisms underlying their biological and pathophysiological actions remain elusive. Within this review, we aimed to summarize the current knowledge on the biochemical and biophysical properties of the most common sphingoid bases and to discuss their importance in health and disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0163-7827
Date of First Compliant Deposit: 23 August 2019
Date of Acceptance: 21 May 2019
Last Modified: 09 Nov 2023 22:19
URI: https://orca.cardiff.ac.uk/id/eprint/125092

Citation Data

Cited 21 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics