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Mammalian sphingoid bases: Biophysical, physiological and pathological properties

Carreira, A.C., Santos, T.C., Lone, M.A., Zupancic, E., Lloyd-Evans, Emyr, de Almeida, R.F.M., Hornemann, T. and Silva, L.C. 2019. Mammalian sphingoid bases: Biophysical, physiological and pathological properties. Progress in Lipid Research 75 , 100988. 10.1016/j.plipres.2019.100988

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Sphingoid bases encompass a group of long chain amino alcohols which form the essential structure of sphingolipids. Over the last years, these amphiphilic molecules were moving more and more into the focus of biomedical research due to their role as bioactive molecules. In fact, free sphingoid bases interact with specific receptors and target molecules, and have been associated with numerous biological and physiological processes. In addition, they can modulate the biophysical properties of biological membranes. Several human diseases are related to pathological changes in the structure and metabolism of sphingoid bases. Yet, the mechanisms underlying their biological and pathophysiological actions remain elusive. Within this review, we aimed to summarize the current knowledge on the biochemical and biophysical properties of the most common sphingoid bases and to discuss their importance in health and disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0163-7827
Date of First Compliant Deposit: 23 August 2019
Date of Acceptance: 21 May 2019
Last Modified: 25 May 2020 02:05

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