Thompson, Aiysha, Griffiths, James S., Walker, Louise, Matos da Fonseca, Diogo, Lee, Keunsook K., Taylor, Philip R., Gow, Neil A. R. and Orr, Selinda J.
2019.
Dependence on Dectin-1 varies with multiple candida species.
Frontiers in Microbiology
10
, 1800.
10.3389/fmicb.2019.01800
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Abstract
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Frontiers Media |
ISSN: | 1664-302X |
Funders: | Wellcome Trust |
Date of First Compliant Deposit: | 18 September 2019 |
Date of Acceptance: | 22 July 2019 |
Last Modified: | 13 Dec 2020 02:21 |
URI: | http://orca.cf.ac.uk/id/eprint/125516 |
Citation Data
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