Dependence on Dectin-1 varies with multiple candida species

Thompson, Aiysha, Griffiths, James S., Walker, Louise, Matos da Fonseca, Diogo, Lee, Keunsook K., Taylor, Philip R., Gow, Neil A. R. and Orr, Selinda J. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10 , 1800. 10.3389/fmicb.2019.01800

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Abstract

Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is important for host immunity to C. albicans and C. glabrata, however, whether Dectin-1 is important for host defense against C. tropicalis or C. parapsilosis is unknown. Therefore, we compared the involvement of Dectin-1 in response to these four diverse Candida spp. We found that Dectin-1 mediates innate cytokine responses to these Candida spp. in a species- and cell-dependent manner. Dectin-1 KO mice succumbed to infection with highly virulent C. albicans while they mostly survived infection with less virulent Candida spp. However, Dectin-1 KO mice displayed increased fungal burden following infection with each Candida spp. Additionally, T cells from Dectin-1 KO mice displayed enhanced effector functions likely due to the inability of Dectin-1 KO mice to clear the infections. Together, these data indicate that Dectin-1 is important for host defense to multiple Candida spp., although the specific roles for Dectin-1 varies with different Candida spp.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Frontiers Media
ISSN:	1664-302X
Funders:	Wellcome Trust
Date of First Compliant Deposit:	18 September 2019
Date of Acceptance:	22 July 2019
Last Modified:	30 Nov 2019 06:50
URI:	http://orca.cf.ac.uk/id/eprint/125516

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