Medicinal plants with multiple effects on Diabetes Mellitus and its complications: A systematic review

Nazarian-Samani, Zeinab, Sewell, Robert, Lorigooini, Zahra and Rafieian-Kopaei, Mahmoud 2018. Medicinal plants with multiple effects on Diabetes Mellitus and its complications: A systematic review. Current Diabetes Reports 18 (10) , p. 72. 10.1007/s11892-018-1042-0

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Abstract

Purpose of Review This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension and/or hyperlipidemia. Recent Findings Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by: stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, inhibiting the secretion of glucagon-like peptide-1 (GLP-1), inhibiting advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen- or nitrogen- species: ROS/RNS) up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4) and preventing development of insulin resistance. Summary Not only are medicinal plants effective in diabetes mellitus, but many of them also possess a variety of effects on other disease states, including the complications of diabetes. Such plants may be appropriate alternatives or adjuncts to available antidiabetic medications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Diabetes mellitus, Medicinal plants, Nephropathy, Neuropathy
Publisher:	Current Medicine Group
ISSN:	1534-4827
Funders:	unspecified
Date of First Compliant Deposit:	30 September 2019
Date of Acceptance:	13 August 2018
Last Modified:	07 Nov 2023 11:57
URI:	https://orca.cardiff.ac.uk/id/eprint/125718

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