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Wnt ligand and receptor patterning in the liver

Valle-Encinas, Eider and Dale, Trevor C. 2020. Wnt ligand and receptor patterning in the liver. Current Opinion in Cell Biology 62 , pp. 17-25. 10.1016/j.ceb.2019.07.014

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Abstract

In the liver, the tight spatiotemporal regulation of Wnt/β-catenin signaling is required to establish and maintain a metabolic form of tissue polarity termed zonation. In this review, we discuss the latest technologies applied in the study of liver zonation and provide a summary of the Wnt ligand and receptor expression patterns in the hepatic lobule. We further discuss the mechanisms, by which Wnt instructive cues might be spatially confined and propagated along the central vein-portal triad axis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0955-0674
Date of First Compliant Deposit: 10 October 2019
Date of Acceptance: 24 July 2019
Last Modified: 27 Nov 2020 01:05
URI: http://orca.cf.ac.uk/id/eprint/125974

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