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Regiospecific Synthesis of α-Alkoxy and α-Alkylthio-1-alkyl-1,2,4-triazoles from Aldehydes and Glyoxals

Smith, Keith, Small, Andrew and Hutchings, Michael G. 1991. Regiospecific Synthesis of α-Alkoxy and α-Alkylthio-1-alkyl-1,2,4-triazoles from Aldehydes and Glyoxals. Synlett (7) , pp. 485-486. 10.1055/s-1991-20770

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Abstract

Reaction between aliphatic aldehydes or glyoxals (RCOCHO) and 1,2,4-triazole followed by mesyl chloride gives α-mesylates of 1-alkyl-1,2,4-triazole, regiospecifically. Mesylate ion is readily displaced by alkoxide, aryloxide, alkylthiolate, or arylthiolate nucleophiles to give the corresponding α-functionalised 1-alkyl-1,2,4-triazoles, in good yield.

Item Type: Article
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Additional Information: Letter
Publisher: Georg Thieme Verlag
ISSN: 0936-5214
Last Modified: 04 Jun 2017 02:51
URI: http://orca.cf.ac.uk/id/eprint/12656

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