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Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

Osimo, Emanuele F., Stochl, Jan, Zammit, Stan, Lewis, Glyn, Jones, Peter B. and Khandaker, Golam M. 2019. Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort. Comprehensive Psychiatry , 152143. 10.1016/j.comppsych.2019.152143

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Abstract

Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.

Item Type: Article
Date Type: Published Online
Schools: Medicine
Publisher: WB Saunders
ISSN: 0010-440X
Date of First Compliant Deposit: 7 November 2019
Date of Acceptance: 26 October 2019
Last Modified: 11 Nov 2019 14:00
URI: http://orca.cf.ac.uk/id/eprint/126634

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