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Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants

Swaden Lewis, Katie, Richards, Alexander, Karlsson, Robert, Leonenko, Ganna, Jones, Samuel, Jones, Hannah, Gordon-Smith, K., Forty, Liz, Escott-Price, V, Owen, Michael J, Weedon, M., Jones, Lisa, Craddock, Nick, Jones, Ian, Landén, Mikael, O'Donovan, Michael and Di Florio, Arianna 2019. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 10.1001/jamapsychiatry.2019.4079

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Abstract

Question: Does genetic liability to insomnia, hypersomnia, and chronotype differentiate subtypes of bipolar disorder? Findings: In this case-control study of 4672 participants with bipolar disorder and 5714 control participants, individuals with bipolar disorder I had significantly greater genetic liability to longer sleep duration, whereas individuals with bipolar disorder II had significantly greater genetic liability to insomnia; these findings were replicated in an independent sample. Individuals with bipolar subtypes did not differ in genetic liability to morning or evening chronotype. Meaning: Associations between polygenic liability to insomnia and hypersomnia and clinical strata within bipolar disorder are shown in this study for the first time, to our knowledge.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: American Medical Association (AMA)
ISSN: 2168-622X
Funders: Wellcome Trust, MRC
Date of First Compliant Deposit: 16 January 2020
Date of Acceptance: 30 September 2019
Last Modified: 16 Jan 2020 15:37
URI: http://orca.cf.ac.uk/id/eprint/126847

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