Allen, Benjamin D. W., Mishra, Deepak, Seastram, Alex C., McBride, Tom, Wirth, Thomas, Browne, Duncan L. and Morrill, Louis C.
2019.
Manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols via alkoxy radicals.
Organic Letters
21
(22)
, pp. 9241-9246.
10.1021/acs.orglett.9b03652
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Official URL: http://dx.doi.org/10.1021/acs.orglett.9b03652
Abstract
A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on a gram scale.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Cardiff Catalysis Institute (CCI) |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
Funders: | EPSRC |
Date of First Compliant Deposit: | 15 November 2019 |
Date of Acceptance: | 30 October 2019 |
Last Modified: | 06 Jan 2021 02:35 |
URI: | http://orca.cf.ac.uk/id/eprint/126861 |
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