Budia, Irene, Alvarez-Arenas, Arturo, Woolley, Thomas, Calvo, Gabriel and Belmonte-Beitia, Juan
2019.
Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical models.
Interface
16
(161)
, 20190665.
10.1098/rsif.2019.0665
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Official URL: http://dx.doi.org/10.1098/rsif.2019.0665
Abstract
We optimize radiotherapy administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between radiotherapy sessions, may lead to better tumour control. The clinical implications of our results are also presented.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Mathematics |
Subjects: | Q Science > QA Mathematics R Medicine > R Medicine (General) |
Publisher: | Royal Society, The |
ISSN: | 1742-5662 |
Date of First Compliant Deposit: | 19 November 2019 |
Date of Acceptance: | 19 November 2019 |
Last Modified: | 15 Mar 2020 02:47 |
URI: | http://orca.cf.ac.uk/id/eprint/126893 |
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