Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical models

Budia, Irene, Alvarez-Arenas, Arturo, Woolley, Thomas, Calvo, Gabriel and Belmonte-Beitia, Juan 2019. Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical models. Interface

[img]
Preview
PDF - Accepted Post-Print Version
Download (1MB) | Preview

Abstract

We optimize radiotherapy administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between radiotherapy sessions, may lead to better tumour control. The clinical implications of our results are also presented.

Item Type: Article
Status: In Press
Schools: Mathematics
Subjects: Q Science > QA Mathematics
R Medicine > R Medicine (General)
Publisher: Royal Society, The
ISSN: 1742-5662
Date of First Compliant Deposit: 19 November 2019
Date of Acceptance: 18 October 2019
Last Modified: 19 Nov 2019 12:30
URI: http://orca.cf.ac.uk/id/eprint/126893

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics