Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical models

Budia, Irene, Alvarez-Arenas, Arturo, Woolley, Thomas, Calvo, Gabriel and Belmonte-Beitia, Juan 2019. Radiation protraction schedules for low-grade gliomas: A comparison between different mathematical models. Interface 16 (161) , 20190665. 10.1098/rsif.2019.0665

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Abstract

We optimize radiotherapy administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between radiotherapy sessions, may lead to better tumour control. The clinical implications of our results are also presented.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Mathematics
Subjects:	Q Science > QA Mathematics R Medicine > R Medicine (General)
Publisher:	Royal Society, The
ISSN:	1742-5662
Date of First Compliant Deposit:	19 November 2019
Date of Acceptance:	19 November 2019
Last Modified:	15 Mar 2020 02:47
URI:	http://orca.cf.ac.uk/id/eprint/126893

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