Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Regioselective three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers

Jones, D. Heulyn, Kay, Steven T., McLellan, Jayde A., Kennedy, Alan R. and Tomkinson, Nicholas C. O. 2017. Regioselective three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers. Organic Letters 19 (13) , pp. 3512-3515. 10.1021/acs.orglett.7b01481

Full text not available from this repository.

Abstract

A novel three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers is described. Treatment of an electron-deficient pyridine N-oxide with an acyl chloride in the presence of a cyclic ether at 25–50 °C leads to a substituted pyridine as a single regioisomer in up to 58% isolated yield. Isotopic-labeling experiments and substrate scope support the reaction proceeding through a carbene intermediate.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 11 Dec 2019 15:15
URI: http://orca.cf.ac.uk/id/eprint/126913

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item