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Using genetics to examine a general liability to childhood psychopathology

Riglin, Lucy, Thapar, Ajay, Leppert, Beate, Martin, Joanna, Richards, Alexander, Anney, Richard, Davey Smith, George, Tilling, Kate, Stegiakouli, Evie, Lahey, Benjamin, O'Donovan, Michael, Collishaw, Stephan and Thapar, Anita 2019. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 10.1007/s10519-019-09985-4

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Abstract

Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general “p” factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood “p” factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general “p” factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Springer Verlag (Germany)
ISSN: 0001-8244
Funders: Wellcome Trust
Date of First Compliant Deposit: 26 November 2019
Date of Acceptance: 22 November 2019
Last Modified: 01 Jan 2020 00:45
URI: http://orca.cf.ac.uk/id/eprint/127101

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