Ward, Simon E., Harries, Mark H., Aldegheri, Laura, Bradford, Andrea M., Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R. and Woolley, Marie
2020.
Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile.
Journal of Psychopharmacology
34
(1)
, pp. 93-102.
10.1177/0269881119872198
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Abstract
There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disorders. However, the challenge is to increase AMPA receptor (AMPAR) function sufficient to enhance cognitive function but not to the extent that there are mechanism-related pro-convulsant or convulsant side effects. In this present study, we report the preclinical pharmacology data for MDI-222, an AMPAR PAM which enhances cognition but has a much reduced side-effect (i.e. convulsant) liability relative to other molecules of this mechanism.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Biosciences |
Publisher: | SAGE |
ISSN: | 0269-8811 |
Date of First Compliant Deposit: | 2 January 2020 |
Date of Acceptance: | 28 July 2019 |
Last Modified: | 25 Nov 2020 05:28 |
URI: | http://orca.cf.ac.uk/id/eprint/128151 |
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