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Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: An arterial spin labeling study

Saxena, Neeraj, Gili, Tommaso, Diukova, Ana, Huckle, Danielle, Hall, Judith E. and Wise, Richard G. 2019. Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: An arterial spin labeling study. Frontiers in Physiology 10 , 1541. 10.3389/fphys.2019.01541

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Abstract

Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. Cerebral perfusion change under an assumption of intact neurovascular coupling is an indicator of change in large-scale neural activity. In this experiment, we have investigated resting state cerebral blood flow (CBF) changes in the human brain during mild sedation, with propofol. Arterial spin labeling (ASL) provides a non-invasive, reliable, and robust means of measuring cerebral blood flow (CBF) and can therefore be used to investigate central drug effects. Mild propofol sedation-related CBF changes were studied at rest (n = 15), in a 3 T MR scanner using a PICORE-QUIPSS II ASL technique. CBF was reduced in bilateral paracingulate cortex, premotor cortex, Broca’s areas, right superior frontal gyrus and also the thalamus. This cerebral perfusion study demonstrates that propofol induces suppression of key cortical (frontal lobe) and subcortical (thalamus) regions during mild sedation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Frontiers Media
ISSN: 1664-042X
Funders: Wellcome Trust
Date of First Compliant Deposit: 6 January 2020
Date of Acceptance: 5 December 2019
Last Modified: 10 Sep 2020 01:22
URI: http://orca.cf.ac.uk/id/eprint/128247

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