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Typical and aberrant functional brain flexibility: lifespan development and aberrant organization in traumatic brain injury and dyslexia

Dimitriadis, Stavros I., Simos, Panagiotis G., Fletcher, Jack M. and Papanicolaou, Andrew C. 2019. Typical and aberrant functional brain flexibility: lifespan development and aberrant organization in traumatic brain injury and dyslexia. Brain Sciences 9 (12) , 380. 10.3390/brainsci9120380

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Abstract

Intrinsic functional connectivity networks derived from different neuroimaging methods and connectivity estimators have revealed robust developmental trends linked to behavioural and cognitive maturation. The present study employed a dynamic functional connectivity approach to determine dominant intrinsic coupling modes in resting-state neuromagnetic data from 178 healthy participants aged 8–60 years. Results revealed significant developmental trends in three types of dominant intra- and inter-hemispheric neuronal population interactions (amplitude envelope, phase coupling, and phase-amplitude synchronization) involving frontal, temporal, and parieto-occipital regions. Multi-class support vector machines achieved 89% correct classification of participants according to their chronological age using dynamic functional connectivity indices. Moreover, systematic temporal variability in functional connectivity profiles, which was used to empirically derive a composite flexibility index, displayed an inverse U-shaped curve among healthy participants. Lower flexibility values were found among age-matched children with reading disability and adults who had suffered mild traumatic brain injury. The importance of these results for normal and abnormal brain development are discussed in light of the recently proposed role of cross-frequency interactions in the fine-grained coordination of neuronal population activity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: MDPI
ISSN: 2076-3425
Date of First Compliant Deposit: 7 January 2020
Date of Acceptance: 12 December 2019
Last Modified: 08 Jan 2020 11:30
URI: http://orca.cf.ac.uk/id/eprint/128276

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