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Saccharomyces cerevisiae: oscillatory orchestration of growth

Lloyd, David 2019. Saccharomyces cerevisiae: oscillatory orchestration of growth. Advancing Frontiers in Mycology & Mycotechnology: Basic and Applied Aspects of Fungi, Springer, pp. 181-214. (10.1007/978-981-13-9349-5_7)

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It is important to understand the structure and function of Baker’s yeast as it serves as an excellent model, not only for many other fungi but also for almost all eukaryotic cell systems, including those of humans and hence biomedicine. In 1996, Saccharomyces cerevisiae became the first genetically defined eukaryotic organism to be sequenced: 6604 genes (> 400 orthologous with, and replaceable by human ones). Although its evolution has diverged for approximately 1.5 billion years from that of human cells, yeast research provides basic clues and insights into the molecular deficiencies and disorders of many human conditions: mitochondrial dysfunction, cellular division, apoptosis, diabetes, obesity, the accompaniments of old age, cancers, and “dynamic diseases” (neuropsychiatric conditions, e.g., many sleep disorders, depression). Dynamic maintenance of redox status and balanced energy supply and demand is crucial for optimum function and survival of yeast and of all cells. Recent advances in optoelectronics enable fast and continuous dynamic interrogation of processes in vivo. In this chapter, I outline the exquisite time order of molecular, metabolic, and biosynthetic events and processes that are organized with a precision that is commensurate with both spatial and temporal organization and that finds a coherence and resonance universally in life processes.

Item Type: Book Section
Status: Published
Schools: Biosciences
Publisher: Springer
ISBN: 978-981-13-9348-8
Last Modified: 13 Jan 2020 15:45

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