ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Jimenez-Pascual, Ana, Lathia, Justin D. and Siebzehnrubl, Florian A. 2019. ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & Cellular Oncology 7 (1) , 1684787. 10.1080/23723556.2019.1684787

Preview

PDF - Accepted Post-Print Version Download (81kB) | Preview

Abstract

Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor autocrine signaling loop, which can be blocked pharmacologically.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
ISSN:	2372-3556
Date of First Compliant Deposit:	13 January 2020
Date of Acceptance:	22 October 2019
Last Modified:	26 Nov 2020 08:30
URI:	http://orca.cf.ac.uk/id/eprint/128458

Actions (repository staff only)

Edit Item