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The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA

Bonsignore, Riccardo, Russo, Fabrizia, Terenzi, Alessio, Spinello, Angelo, Lauria, Antonino, Gennaro, Giuseppe, Almerico, Anna Maria, Keppler, Bernhard K. and Barone, Giampaolo 2018. The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA. Journal of Inorganic Biochemistry 178 , pp. 106-114. 10.1016/j.jinorgbio.2017.10.010

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Abstract

The duplex and G-quadruplex DNA-binding of six nickel(II) and zinc(II) complexes of three salphen-like ligands (salphen = N,N′-bis-salicylidene-1,2-phenylenediaminato) was investigated by UV–visible absorption and circular dichroism spectroscopy. The results obtained, in particular the values of the DNA-binding constants, Kb, point out that the nickel(II) complexes show a higher affinity toward both duplex and G-quadruplex DNA, compared to the analogous zinc(II) complexes. Interestingly, the zinc(II) complexes possess high selectivity toward G-quadruplex DNA, being negligible their binding with duplex DNA. Molecular dynamics (MD) simulations provided atomistic models for the interpretation of the binding of the zinc(II) complexes with G-quadruplex DNA, allowing a structural comparison of the three salphen-like ligands, due to the presence of different substituents (H, F, CF3) on the position 4 of the phenyl ring on the N,N′ bridge.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISSN: 0162-0134
Date of Acceptance: 25 October 2017
Last Modified: 16 Oct 2020 01:45
URI: http://orca.cf.ac.uk/id/eprint/128679

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