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Fibrosis in dysthyroid eye disease

Ludgate, Marian 2019. Fibrosis in dysthyroid eye disease. Eye 10.1038/s41433-019-0731-5

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Dysthyroid eye disease is a rare condition, mainly found in people with Graves’ hyperthyroidism. Autoimmune responses to thyroid/orbit shared antigens drive extensive tissue remodelling. This includes excess adipogenesis and over-production of extra-cellular matrix, which both tend to occur in the earlier ‘active’ inflammatory stages of disease. With time these give way to fibrosis, which has a profound impact on eye motility and may be life-long. Progress has been made in identifying the shared autoantigen(s) and the role of specific T cells and autoantibodies in remodelling, which have facilitated development of novel therapies. However relatively little is known of the autoimmune processes under-pinning fibrosis and currently there are no adequate medical treatments.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Additional Information: Conference Proceeding - CAMBRIDGE OPHTHALMOLOGICAL SYMPOSIUM Fibrosis and the Eye. Cambridge Sept 4-6 2019
Publisher: Springer Nature
ISSN: 0950-222X
Date of First Compliant Deposit: 17 January 2020
Date of Acceptance: 28 October 2019
Last Modified: 31 Jul 2020 01:25

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