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Modulation of innate and adaptive immunity by cytomegaloviruses

Berry, Richard, Watson, Gabrielle M., Jonjic, Stipan, Degli-Esposti, Mariapia A. and Rossjohn, Jamie 2020. Modulation of innate and adaptive immunity by cytomegaloviruses. Nature Reviews Immunology 20 , pp. 113-127. 10.1038/s41577-019-0225-5

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The coordinated activities of innate and adaptive immunity are critical for effective protection against viruses. To counter this, some viruses have evolved sophisticated strategies to circumvent immune cell recognition. In particular, cytomegaloviruses encode large arsenals of molecules that seek to subvert T cell and natural killer cell function via a remarkable array of mechanisms. Consequently, these ‘immunoevasins’ play a fundamental role in shaping the nature of the immune system by driving the evolution of new immune receptors and recognition mechanisms. Here, we review the diverse strategies adopted by cytomegaloviruses to target immune pathways and outline the host’s response.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Research
ISSN: 1474-1733
Date of Acceptance: 16 September 2019
Last Modified: 31 Jan 2020 11:15

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