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Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications

Sheil, Anna I., Ayre, Wayne N., Blom, Ashley W., Hallam, K., Heard, Peter J., Payton, Oliver, Picco, Loren and Mansell, Jason P. 2020. Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications. Journal of Orthopaedic Translation 23 , pp. 140-151. 10.1016/j.jot.2020.02.002
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Abstract

Aseptic loosening of total joint replacements (TJR’s) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone it is estimated that £135m is spent annually on revision arthroplasties. Enhancing the longevity of titanium implants will help reduce the incidence and overall cost of failed devices. In realising the development of a superior titanium technology we exploited the natural affinity of titanium for phosphonic acids and developed a facile means of coating the metal with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1- phosphonate (FHBP), a phosphatase-resistant analogue of lysophosphatidic acid (LPA). Importantly LPA and selected LPA analogues like FHBP synergistically cooperate with calcitriol to promote human osteoblast formation and maturation. Herein we provide evidence that simply immersing titanium in aqueous solutions of FHBP afforded a surface that was superior to unmodified metal at enhancing osteoblast maturation. Importantly FHBP-functionalised titanium remained stable to 2 years of ambient storage, resisted ~35kGy of gamma irradiation and survived implantation into a bone substitute (SawboneTM) and irrigation. The facile step we have taken to modify titanium and the robustness of the final surface finish are appealing properties that are likely to attract the attention of implant manufacturers in the future.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Publisher: Elsevier
ISSN: 2214-031X
Date of First Compliant Deposit: 11 February 2020
Date of Acceptance: 7 February 2020
Last Modified: 27 Aug 2020 13:44
URI: http://orca.cf.ac.uk/id/eprint/129507

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