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True or false? challenges and recent highlights in the development of aspirin prodrugs

Willetts, Steffan and Foley, David W. 2020. True or false? challenges and recent highlights in the development of aspirin prodrugs. European Journal of Medicinal Chemistry 192 , 112200. 10.1016/j.ejmech.2020.112200
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Abstract

Aspirin is a widely used medicine for a variety of indications. It is unique amongst non-steroidal anti-inflammatory drugs (NSAIDs) in that it causes irreversible acetylation of COX enzymes. Like all NSAIDs however, aspirin causes severe gastrointestinal side-effects, in particular with chronic administration. Prodrugs of aspirin have been proposed as a solution to these side-effects. However, identifying true prodrugs of aspirin, rather than salicylic acid, has proven challenging. This review details the challenges and highlights recent progress in the development of such prodrugs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0223-5234
Date of First Compliant Deposit: 4 March 2020
Date of Acceptance: 28 February 2020
Last Modified: 07 Apr 2020 16:42
URI: http://orca.cf.ac.uk/id/eprint/130134

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