Willetts, Steffan and Foley, David W. ORCID: https://orcid.org/0000-0001-8449-4754 2020. True or false? challenges and recent highlights in the development of aspirin prodrugs. European Journal of Medicinal Chemistry 192 , 112200. 10.1016/j.ejmech.2020.112200 |
Preview |
PDF
- Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (647kB) | Preview |
Abstract
Aspirin is a widely used medicine for a variety of indications. It is unique amongst non-steroidal anti-inflammatory drugs (NSAIDs) in that it causes irreversible acetylation of COX enzymes. Like all NSAIDs however, aspirin causes severe gastrointestinal side-effects, in particular with chronic administration. Prodrugs of aspirin have been proposed as a solution to these side-effects. However, identifying true prodrugs of aspirin, rather than salicylic acid, has proven challenging. This review details the challenges and highlights recent progress in the development of such prodrugs.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Publisher: | Elsevier |
ISSN: | 0223-5234 |
Date of First Compliant Deposit: | 4 March 2020 |
Date of Acceptance: | 28 February 2020 |
Last Modified: | 06 Nov 2023 19:32 |
URI: | https://orca.cardiff.ac.uk/id/eprint/130134 |
Citation Data
Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |