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Extracellular vesicle therapy for retinal diseases

Mead, Ben and Tomarev, Stanislav 2020. Extracellular vesicle therapy for retinal diseases. Progress in Retinal and Eye Research , -. 10.1016/j.preteyeres.2020.100849
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Abstract

Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more recent studies have interrogated their potential as a therapeutic that may replace paracrine-acting cell therapies. The retina is a conveniently accessible component of the central nervous system and the proposed paradigm for the testing of many cell therapies. Recently, several studies have been published demonstrating that the delivery of EV/exosomes into the eye can elicit significant therapeutic effects in several models of retinal disease. We summarize results from currently available studies, demonstrating their efficacy in multiple eye disease models as well as highlighting where future research efforts should be directed.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Optometry and Vision Sciences
Publisher: Elsevier
ISSN: 1350-9462
Funders: N/A
Date of First Compliant Deposit: 10 March 2020
Date of Acceptance: 6 March 2020
Last Modified: 13 Mar 2020 04:41
URI: http://orca.cf.ac.uk/id/eprint/130282

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