Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Mikhaylov, Roman, Wu, Fangda, Wang, Hanlin, Clayton, Aled, Sun, Chao, Xie, Zhihua, Liang, Dongfang, Dong, Yinhua, Yuan, Fan, Moschou, Despina, Wu, Zhenlin, Shen, Minghong, Yang, Jian, Fu, Yong Qing, Yang, Zhiyong, Burton, Christian, Errington, Rachel, Wiltshire, Marie and Yang, Xin 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20 (10) , pp. 1807-1814. 10.1039/C9LC01192G Item availability restricted.

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Abstract

Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. Reducing cost and time for manufacturing surface acoustic wave (SAW)-based acoustofluidic devices could facilitate rapid applications of the SAW technology and attract more researchers into this field. We present herein a novel but simple technology to form a cost-effective SAW device by stacking electrodes made from printed circuit board (PCB) and piezoelectric substrate to generate acoustic waves. PCB-based SAW devices (PCB-SAW) have been characterized and compared to the conventional SAW devices made using the cleanroom fabrication processes. The PCB-SAW devices were successfully used to manipulate microparticles within droplets and microchannels, which showed similar performance with those previously achieved using the standard SAW devices. The PCB-SAW was further used as an acoustic tweezer to precisely pattern the human lung cancer cells inside the microchannel. Cell viability tests proved that the PCB-SAW possessed good biocompatibility to be potentially applied as a cost-effective and precise tool for acoustophoresis and beyond.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Engineering
Publisher:	Royal Society of Chemistry
ISSN:	1473-0197
Date of First Compliant Deposit:	2 June 2020
Date of Acceptance:	3 April 2020
Last Modified:	30 Jun 2020 14:39
URI:	http://orca.cf.ac.uk/id/eprint/131002

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