Mikhaylov, Roman, Wu, Fangda, Wang, Hanlin, Clayton, Aled, Sun, Chao, Xie, Zhihua, Liang, Dongfang, Dong, Yinhua, Yuan, Fan, Moschou, Despina, Wu, Zhenlin, Shen, Minghong, Yang, Jian, Fu, Yong Qing, Yang, Zhiyong, Burton, Christian, Errington, Rachel, Wiltshire, Marie and Yang, Xin
2020.
Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB.
Lab on a Chip
20
(10)
, pp. 1807-1814.
10.1039/C9LC01192G
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Abstract
Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. Reducing cost and time for manufacturing surface acoustic wave (SAW)-based acoustofluidic devices could facilitate rapid applications of the SAW technology and attract more researchers into this field. We present herein a novel but simple technology to form a cost-effective SAW device by stacking electrodes made from printed circuit board (PCB) and piezoelectric substrate to generate acoustic waves. PCB-based SAW devices (PCB-SAW) have been characterized and compared to the conventional SAW devices made using the cleanroom fabrication processes. The PCB-SAW devices were successfully used to manipulate microparticles within droplets and microchannels, which showed similar performance with those previously achieved using the standard SAW devices. The PCB-SAW was further used as an acoustic tweezer to precisely pattern the human lung cancer cells inside the microchannel. Cell viability tests proved that the PCB-SAW possessed good biocompatibility to be potentially applied as a cost-effective and precise tool for acoustophoresis and beyond.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Engineering |
Publisher: | Royal Society of Chemistry |
ISSN: | 1473-0197 |
Date of First Compliant Deposit: | 2 June 2020 |
Date of Acceptance: | 3 April 2020 |
Last Modified: | 23 Jan 2021 04:50 |
URI: | http://orca.cf.ac.uk/id/eprint/131002 |
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