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The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007?2014: Insights from the British Cardiovascular Intervention Society database

Hussain, Hussain I., Protty, Majd B., Gallagher, Sean, Al-Raisi, Sara, Aldalati, Omar, Farooq, Vasim, Sharp, Andrew S. P., Anderson, Richard and Kinnaird, Tim 2020. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007?2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 10.1002/ccd.28933

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Abstract

Background Percutaneous coronary intervention (PCI) is increasingly utilized for treatment of coronary disease involving the unprotected left main stem (ULMS). However, no studies to date have examined the outcomes of such interventions when complicated by coronary perforation (CP). Methods Using the British Cardiovascular Intervention society (BCIS) database, data were analyzed on all ULMS‐PCI procedures complicated by CP in England and Wales between 2007 and 2014. Multivariate logistic regressions were used to identify predictors of ULMS CP and to evaluate the association between this complication and outcomes. Results During 10,373 ULMS‐PCI procedures, CP occurred more frequently than in non‐ULMS‐PCI (0.9 vs. 0.4%, p < .001) with a stable annual incidence. Covariates associated with CP included number of stents used, female gender, use of rotational atherectomy and chronic total occlusion (CTO) intervention. Adjusted odds of adverse outcomes for ULMS‐PCI complicated by CP were higher for peri‐procedural complications including cardiogenic shock, tamponade, side‐branch loss, DC cardioversion, in‐hospital major bleeding, transfusion requirement, and peri‐procedural myocardial infarction. There were also significantly increased odds for in‐hospital major adverse cardiac events (MACCE, OR 8.961, 95% CI [4.902–16.383]) and 30‐day mortality (OR 5.301, 95% CI [2.741–10.251]). Conclusions CP is an infrequent event during ULMS‐PCI and is predicted by female gender, rotational atherectomy, CTO interventions or number of stents used. CP was associated with significantly higher odds of mortality and morbidity, but at rates similar to previously published all‐comer PCI complicated by CP.

Item Type: Article
Date Type: Published Online
Status: In Press
Schools: Medicine
Publisher: Wiley
ISSN: 1522-1946
Date of First Compliant Deposit: 1 May 2020
Date of Acceptance: 13 April 2020
Last Modified: 06 May 2020 01:20
URI: http://orca.cf.ac.uk/id/eprint/131369

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