Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Particle-induced oxidative damage by indoor size-segregated particulate matter from coal-burning homes in the Xuanwei lung cancer epidemic area, Yunnan Province, China

Feng, Xiaolei, Shao, Longyi, Xi, Chunxiu, Jones, Tim, Zhang, Daizhou and Berube, Kelly 2020. Particle-induced oxidative damage by indoor size-segregated particulate matter from coal-burning homes in the Xuanwei lung cancer epidemic area, Yunnan Province, China. Chemosphere 256 , 127058. 10.1016/j.chemosphere.2020.127058
Item availability restricted.

[img] PDF - Accepted Post-Print Version
Restricted to Repository staff only until 11 May 2021 due to copyright restrictions.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB)

Abstract

Size-segregated samples of airborne particulate matter were collected at the coal-burning homes of the Hutou high lung cancer epidemic village and a comparison site Xize village of the Xuanwei County, Yuanan Province, by an Anderson Cascade Impact Sampler in winter and spring to study the toxicological characteristics of different-sized particles. The DNA damage caused by the water-soluble fractions of these size-segregated particles was analyzed by the plasmid scission assay, and the trace element compositions were determined by Inductively Coupled Plasma Mass Spectrometry. The DNA damage rate from the airborne particles in the high lung cancer incidence area was higher than that in Xize village. The different-sized particles have highly varying DNA damage rates, with the values being greater in the small size range than in the large size range. The particle-induced DNA damage rates had a significantly positive correlation with total water-soluble trace elements. Further analysis of the individual elements indicated that the water-soluble heavy metals Zn, Cu, Cd, Rb, Cs, and Sb had a positive correlation with the particle-induced DNA damage, implying that these water-soluble heavy metals played an important role in the DNA damage. The Sr had a negative correlation with the particle-induced DNA damage, suggesting that the water-soluble Sr might counter DNA damage. The mass concentrations of the total and individual water-soluble trace elements were mostly enriched in the small particle size ranges, thus implying the indoor airborne particles in the small size ranges would have a higher health risk.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Earth and Ocean Sciences
Biosciences
Publisher: Elsevier
ISSN: 0045-6535
Date of First Compliant Deposit: 28 May 2020
Date of Acceptance: 10 May 2020
Last Modified: 09 Nov 2020 14:00
URI: http://orca.cf.ac.uk/id/eprint/131964

Citation Data

Cited 1 time in Google Scholar. View in Google Scholar

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics