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Metabolic heterogeneity and adaptability in brain tumors

Badr, Christian E., Silver, Daniel J., Siebzehnrubl, Florian A. and Deleyrolle, Loic P. 2020. Metabolic heterogeneity and adaptability in brain tumors. Cellular and Molecular Life Sciences 77 , pp. 5101-5119. 10.1007/s00018-020-03569-w
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Abstract

The metabolic complexity and flexibility commonly observed in brain tumors, especially glioblastoma, is fundamental for their development and progression. The ability of tumor cells to modify their genetic landscape and adapt metabolically, subverts therapeutic efficacy, and inevitably instigates therapeutic resistance. To overcome these challenges and develop effective therapeutic strategies targeting essential metabolic processes, it is necessary to identify the mechanisms underlying heterogeneity and define metabolic preferences and liabilities of malignant cells. In this review, we will discuss metabolic diversity in brain cancer and highlight the role of cancer stem cells in regulating metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic vulnerabilities and examine how intercellular metabolic signaling can shape the tumor microenvironment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer Verlag (Germany)
ISSN: 1420-682X
Date of First Compliant Deposit: 16 June 2020
Date of Acceptance: 28 May 2020
Last Modified: 19 Nov 2020 14:00
URI: http://orca.cf.ac.uk/id/eprint/132486

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