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Post-translational mechanisms of zinc signalling in cancer

Nimmanon, Thirayost and Taylor, Kathryn M. 2019. Post-translational mechanisms of zinc signalling in cancer. In: Fukada, Toshiyuki and Kambe, Taiho eds. Zinc Signaling, Springer, Singapore, pp. 319-345. (10.1007/978-981-15-0557-7_16)

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Abstract

Three groups of proteins are actively involved in the control of intracellular zinc, consisting of ZIP channels (SLC39A), ZnT transporters (SLC30A), and metallothioneins. Malfunctions of many zinc transport proteins, especially those belonging to the ZIP family which increase cytosolic zinc availability, have been associated with cancer. Importantly, post-translational modifications have been reported to play an increasing role in the functional control of ZIP channels. In this chapter, we therefore detail the established role of zinc signalling in cancer, with an emphasis on breast cancer, as well as demonstrate effects of post-translational modifications by phosphorylation and proteolytic cleavage.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Springer, Singapore
ISBN: 978981505560
Last Modified: 19 Jun 2020 15:15
URI: http://orca.cf.ac.uk/id/eprint/132579

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