Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Post-translational mechanisms of zinc signalling in cancer

Nimmanon, Thirayost and Taylor, Kathryn M. ORCID: https://orcid.org/0000-0002-9576-9490 2019. Post-translational mechanisms of zinc signalling in cancer. Fukada, Toshiyuki and Kambe, Taiho, eds. Zinc Signaling, Springer, Singapore, pp. 319-345. (10.1007/978-981-15-0557-7_16)

Full text not available from this repository.

Abstract

Three groups of proteins are actively involved in the control of intracellular zinc, consisting of ZIP channels (SLC39A), ZnT transporters (SLC30A), and metallothioneins. Malfunctions of many zinc transport proteins, especially those belonging to the ZIP family which increase cytosolic zinc availability, have been associated with cancer. Importantly, post-translational modifications have been reported to play an increasing role in the functional control of ZIP channels. In this chapter, we therefore detail the established role of zinc signalling in cancer, with an emphasis on breast cancer, as well as demonstrate effects of post-translational modifications by phosphorylation and proteolytic cleavage.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Springer, Singapore
ISBN: 978981505560
Last Modified: 07 Nov 2022 10:32
URI: https://orca.cardiff.ac.uk/id/eprint/132579

Citation Data

Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item