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Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.

Heng, Julian Ik-Tsen, Nguyen, Laurent, Castro, Diogo S., Zimmer, Céline, Wildner, Hendrik, Armant, Oliver, Skowronska-Krawczyk, Dorota, Bedogni, Francesco, Matter, Jean-Marc, Hevner, Robert and Guillemot, François 2008. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature 10.1038/nature07198

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Abstract

Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex1,2, directly induces the expression of the small GTP-binding protein Rnd2 (ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial migration of cortical neurons similar to that observed when the Neurog2 gene is deleted. Remarkably, restoring Rnd2 expression in Neurog2-mutant neurons is sufficient to rescue their ability to migrate. Our results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration. Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Nature Publishing Group
ISSN: 0028-0836
Last Modified: 06 Jul 2020 12:30
URI: https://orca.cardiff.ac.uk/id/eprint/133010

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