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Manufacturability, mechanical properties, mass-transport properties and biocompatibility of Triply Periodic Minimal Surface (TPMS) scaffolds fabricated by selective laser melting

Ma, Shuai, Tang, Qian, Han, Xiaoxiao, Feng, Qixiang, Song, Jun, Setchi, Rossitza, Liu, Ying, Liu, Yang, Goulas, Athanasios, S. Engstrøm, Daniel, Tse, YauYau and Zhen, Ni 2020. Manufacturability, mechanical properties, mass-transport properties and biocompatibility of Triply Periodic Minimal Surface (TPMS) scaffolds fabricated by selective laser melting. Materials and Design 195 , 109034. 10.1016/j.matdes.2020.109034

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Abstract

Selective laser melting is a promising additive manufacturing technology for manufacturing porous metallic bone scaffolds. Bone repair requires scaffolds that meet various mechanical and biological requirements. This paper addresses this challenge by comprehensively studying the performance of porous scaffolds. The main novelty is exploring scaffolds with different porosities, verifying various aspects of their performance and revealing the effect of their permeability on cell growth. This study evaluates the manufacturability, mechanical behaviour, permeability and biocompatibility of gyroid scaffolds. In simulations, mechanical behaviour and permeability exhibited up to 56% and 73% accuracy, respectively, compared to the experimental data. The compression and permeability experiments showed that the elastic modulus and the permeability of the scaffolds were both in the range of human bones. The morphological experiment showed that manufacturing accuracy increased with greater designed porosity, while the in vitro experiments revealed that permeability played the main role in cell proliferation. The significance of this work is improving the understanding of the effect of design parameters on the mechanical properties, permeability and cell growth of the scaffolds, which will enable the design of porous bone scaffolds with better bone-repair effects.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Publisher: Elsevier
ISSN: 0261-3069
Related URLs:
Date of First Compliant Deposit: 10 August 2020
Date of Acceptance: 3 August 2020
Last Modified: 09 Sep 2020 12:08
URI: http://orca.cf.ac.uk/id/eprint/134039

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