Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases

Coughtrie, Michael W. H., Sharp, Sheila, Maxwell, Keara and Innes, Nicola P. 1998. Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases. Chemico-Biological Interactions 109 (1-3) , pp. 3-27. 10.1016/S0009-2797(97)00117-8

Full text not available from this repository.

Abstract

Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent compound. The range of compounds which are sulfated is enormous, yet we still understand relatively little of the function of this pathway. This review summarises current knowledge of the sulfation system and the enzymes involved, and illustrates how heterologous expression of sulfotransferases (SULTs) and sulfatases is aiding our appreciation of the properties of these important proteins. The role of sulfation in the bioactivation of procarcinogens and promutagens is discussed, and new data on the inhibition of the sulfotransferase(s) involved by common dietary components such as tea and coffee are presented. The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Publisher: Elsevier
ISSN: 0009-2797
Last Modified: 04 Sep 2020 14:00
URI: http://orca.cf.ac.uk/id/eprint/134413

Actions (repository staff only)

Edit Item Edit Item