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Clinical significance of SphK1 in chemotherapy resistance of gastric cancer patients

Gao, Xiangyu 2019. Clinical significance of SphK1 in chemotherapy resistance of gastric cancer patients. MD Thesis, Cardiff University.
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Abstract

Sphingosine kinase 1 (SphK1) is a biologically active lipid which plays a significant role in the growth, survival, migration of the cell, as well as a role in anti-apoptosis and enhances cell immortalization. SphK1 is involved in the crucial S1P signalling pathway which can catalyse sphingosine phosphorylates to S1P in an ATPdependent manner. Our study examined the effect of SphK1 on gastric cancer cell line, its clinical significance in gastric cancer progression and the role in chemoresistance with the prediction that SphK1 is a potential pharmacologic target.Our results demonstrated that the inhibition of SphK1 expression and/or its kinase activity could down-regulate AKT/mTOR survival signalling pathway, leading to reduced chemoresistance of gastric cancer cells, suggesting that SphK1might be a potential novel target for the treatment of gastric cancer.

Item Type: Thesis (MD)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Date of First Compliant Deposit: 7 September 2020
Last Modified: 07 Sep 2020 10:55
URI: http://orca.cf.ac.uk/id/eprint/134681

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