Dambatta, Mubarak B., Santos, Joseph, Bolt, Robert and Morrill, Louis C.
2020.
Transition metal free α-C-alkylation of ketones using secondary alcohols.
Tetrahedron
76
(45)
, 131571.
10.1016/j.tet.2020.131571
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Official URL: http://dx.doi.org/10.1016/j.tet.2020.131571
Abstract
A base-mediated α-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Cardiff Catalysis Institute (CCI) |
Publisher: | Elsevier |
ISSN: | 0040-4020 |
Funders: | Tertiary Education Trust Fund (TETFund) and Cardiff University |
Date of First Compliant Deposit: | 14 September 2020 |
Date of Acceptance: | 1 September 2020 |
Last Modified: | 27 Nov 2020 06:09 |
URI: | http://orca.cf.ac.uk/id/eprint/134828 |
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